Lions vs Cardinals Predictions & Odds in Week 3: Detroit Favored Against Arizona?

👇 Lions vs Cardinals Predictions: Quick Facts 👇

Reference the table below for important facts on this Week 3 matchup.

⭐ Favorite	Lions
⚖️ Lions Win	76%
🔢 Point Spread	DET -4
📊 Moneyline	DET -198
📈 Game Total	O/U 50
✅ Last Verified	May 21, 2025

Are The Lions or Cardinals Favored to Win?

Michigan Sportsbooks are expecting the Lions to beat the Cardinals in their week 3 matchup. Every sportsbook will have different lines so its important to check them all before placing a bet. We also expect all the spread, moneyline and over/under to shift before the week of the game.

What is the Over/Under?

The over/under for this week 3 matchup is set to 50. We expect this number to shift depending on how the Cardinals new rookies adjust to their new roles.

What Is The Moneyline?

The moneyline of DET at -198 and ARI at +164 indicates that the Lions are the favorites to win, meaning you would need to bet $198 on Detroit to win $100. Conversely, a $100 bet on Arizona would yield $164 if they win.

What Is The Point Spread?

The Lions being 4-point favorites against the Cardinals means that they are expected to win by at least 4 points. If you bet on the Lions, they must win by more than 4 points for your bet to be successful. Conversely, if you bet on the Cardinals, they need to either win the game or lose by fewer than 4 points for your bet to win.

Lions Chances To Win vs Cardinals

The Lions are 4-point road favorites over the Cardinals, who are one of the biggest unknowns in the NFC heading into the season. The Lions are -198 on the moneyline, giving them an implied win probability of 66.4%.

How The Lions Win vs Cardinals

The Lions are the much more talented team and it's why they are among the favorites to win the NFC this season. For them to beat the Cardinals, they just need to play their game and avoid turnovers. Look for the Lions to lean heavily on their rushing attack to control the clock and avoid turnovers.

• 📈 Strength: Rushing Offensive, Athletic Defense
• 📉 Weakness: Special Teams, Unproven Secondary

How The Cardinals Win vs Lions

If the Cardinals are going to win this game, they need Kyler Murray to play like a superstar. He'll need to cover up for a bad offensive line and make plays with both of his arms and his legs. On defense, they'll need to be creative because they don't have the talent level to match the Lions. But that doesn't mean it can be done. Look for Arizona to be aggressive in trying to create pressure on Goff in this contest.

• 📈 Strength: Athletic Quarterback, Plenty of Offensive Weapons
• 📉 Weakness: Lack Of Rush, Inexperienced Secondary

How to Bet on the Game

In Michigan and looking to bet on the Lions vs. Cardinals? You have plenty of options. Online betting is available through betting apps like Caesars, BetMGM, and DraftKings, all of which offer live odds for this Week 3 matchup. Alternatively, you can place your bets in person at various casinos that have sportsbooks throughout the state, 

History of Lions vs Cardinals in the 2000's

Below is a list of every time the Lions and the Cardinals matched up in the 2000's:

Date of Game	Location	Lions Score	Cardinals Score
12/19/2021	@ Detroit Lions	30	12
09/27/2020	@ Arizona Cardinals	26	23
09/08/2019	@ Arizona Cardinals	27	27
12/09/2018	@ Arizona Cardinals	17	3
09/10/2017	@ Detroit Lions	35	23
10/11/2015	@ Detroit Lions	17	42
11/16/2014	@ Arizona Cardinals	6	14
09/15/2013	@ Arizona Cardinals	21	25
12/16/2012	@ Arizona Cardinals	10	38
12/20/2009	@ Detroit Lions	24	31
11/11/2007	@ Arizona Cardinals	21	31
11/19/2006	@ Arizona Cardinals	10	17
11/13/2005	@ Detroit Lions	29	21
12/05/2004	@ Detroit Lions	26	12
09/07/2003	@ Detroit Lions	42	24
12/08/2002	@ Arizona Cardinals	20	23
11/18/2001	@ Arizona Cardinals	38	45

All-Time Best Lions Vs Cardinals Games

The Lions and the Cardinals have played 69 times against each other, but they have never met in the postseason. The Lions currently lead the series 35-28-6.

Game 1: Week 1 - 2019 (9-8-2019)

In the opening game of the year, the Lions and Cardinals tied 27-27 in a really exciting game. The Lions jumped out to a 24-6 lead before Kyler Murray and David Johnson went crazy in the second half. Both teams kicked field goals in overtime, but neither was able to separate from one another before the game finished.

Game 2: Week 2 - 2013 (9-15-2013)

This Week 2 matchup featured Carson Palmer against Matthew Stafford, but the real story here was Calvin Johnson, who caught six es for 116 yards and two touchdowns. The Lions jumped out to a 21-16 lead, but it was the Cardinals who scored twice in the fourth quarter, winning 25-21 in Arizona.

Game 3: Week 4 - 1993 (9-26-1993)

This was another early-season matchup where the Cardinals took a 17-16 lead after the first half. But a late fieldgoal by Jason Hanson gave the Lions the lead and they would ultimately win 26-20 to improve to 3-1 on the season.

Last Matchup Between Detroit Lions and Arizona Cardinals

The Detroit Lions shocked the Arizona Cardinals with a 30-12 victory. The Cardinals, who started the day tied for the NFL's best record, couldn't secure a playoff spot, while the Lions, at the bottom of the standings, outperformed them. Jared Goff excelled with 216 ing yards and three touchdowns, while Detroit's defense stifled Murray, limiting him to 257 ing yards and one touchdown. 

Lions Record All-Time Vs Cardinals

• Games Played = 69
• Lions Wins = 35
• Cardinals Wins = 28
• Ties = 6
• Playoff Matchups = 0
• First Matchup = 6-0, Lions W
• Last Matchup = 30-12, Lions W

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